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Purpose

The main objective of this study was to evaluate if the -429T/C, -374T/A and 63 bp deletion polymorphisms in the RAGE gene are associated with diabetic retinopathy (DR) among Type 2 diabetic subjects in a clinic-based population from South India.

Methods

We screened 149 normal glucose tolerant subjects (NGT), 189 Type 2 diabetes subjects without retinopathy (DM) and 190 subjects with DR for these polymorphisms using the PCR-RFLP method. DR was diagnosed by grading color fundus photography. Logistic regression models were used to evaluate the association of individual polymorphisms with DR. Expectation-maximization algorithms were implemented in haplotype tests of association to examine the combined effects of -429T/C and -374T/A polymorphisms on DR.

Results

The allelic frequencies of -429T are 0.83 in NGT, 0.84 in DM and 0.85 in DR subjects, and that of -374T are 0.93 in NGT, 0.92 in DM and 0.88 in DR subjects. The -374 polymorphism was found to be associated with non-proliferative retinopathy when this subgroup was compared to the DM group (OR=1.814, 95% CI=1.005-3.273). However, this association was not obvious when both the subphenotypes of DR (the nonproliferative and proliferative DR groups) were studied jointly. We found no evidence for associations between the -429T/C polymorphism and the DR phenotype. Finally, extension to a 2-SNP haplotype did not reveal any significant statistical difference between the groups (P=0.668).

Conclusion

In this study, we found a modest association with the -374T/A polymorphism in the nonproliferative DR subgroup."xsd:string
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http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/author"Rao M.R."xsd:string
http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/author"Mathias R.A."xsd:string
http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/author"Radha V."xsd:string
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http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/author"Majumder P.P."xsd:string
http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/author"Ramprasad S."xsd:string
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http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/pages"395-401"xsd:string
http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/title"Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India."xsd:string
http://purl.uniprot.org/citations/16440015http://purl.uniprot.org/core/volume"21"xsd:string
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