| http://purl.uniprot.org/citations/16443219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16443219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16443219 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated post-translational modification and subcellular localisation of endogenous platelet-derived growth factor-C (PDGF-C) in human thyroid papillary carcinomas (PTC), non-neoplastic thyroid tissues, and a selection of cultured cell lines. PDGF-C expressed nuclear localisation in 95% of all tested cell types in culture and in 10% of the thyrocytes from both PTC and non-neoplastic tissue. The cell lines expressed two forms of full-length PDGF-C, approximately 39 and approximately 55 kDa, in cell membrane and cytosol, while the approximately 55 kDa form dominated in the nucleus where it was partly chromatin-associated. The approximately 55 kDa form was post-translationally modified by SUMO-1. The putative PDGF-C SUMOylation site is the surface exposed (314)lysine part of a positively charged loop ((312)RPKTGVRGLHK(322)) with characteristics of a nuclear localisation signal. The tissue thyrocytes expressed a non-SUMOylated approximately 43 kDa and the 55 kDa PDGF-C. The SUMO-1 modified approximately 55 kDa PDGF-C expression was low in PTC where the approximately 43 kDa PDGF-C dominated. This is in contrast to non-neoplastic tissue and cultured cells where the SUMOylated approximately 55 kDa PDGF-C was strongly expressed. Our data provide novel evidence for nuclear localisation of PDGF-C, post-translational modification by SUMOylation and the expression of a novel form of PDGF-C in human papillary thyroid carcinomas."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.11.035"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.11.035"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Lillehaug J.R."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Lillehaug J.R."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Martinez A."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Martinez A."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Reigstad L.J."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Reigstad L.J."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Varhaug J.E."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/author | "Varhaug J.E."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/pages | "782-795"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/pages | "782-795"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/title | "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/title | "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16443219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16443219 |
| http://purl.uniprot.org/citations/16443219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16443219 |