http://purl.uniprot.org/citations/16443351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16443351 | http://www.w3.org/2000/01/rdf-schema#comment | "SALL1 has been identified as one of four human homologues of the Drosophila region-specific homeotic gene spalt (sal), encoding zinc finger proteins of characteristic structure. Mutations of SALL1 on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS, OMIM 107480). We have shown previously that SALL1 acts as a strong transcriptional repressor in mammalian cells when fused to a heterologous DNA-binding domain. Here, we report that SALL1 contains two repression domains, one located at the extreme N-terminus of the protein and the other in the central region. SALL1 fragments with the central repression domain exhibited a punctate nuclear distribution pattern at pericentromeric heterochromatin foci in murine NIH-3T3 cells, suggesting an association between repression and heterochromatin localization. The implications of these findings for the pathogenesis of Townes-Brocks syndrome are discussed."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2005.12.005"xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/author | "Netzer C."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/author | "Kohlhase J."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/author | "Bohlander S.K."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/author | "Hinzke M."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/pages | "386-391"xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/title | "Defining the heterochromatin localization and repression domains of SALL1."xsd:string |
http://purl.uniprot.org/citations/16443351 | http://purl.uniprot.org/core/volume | "1762"xsd:string |
http://purl.uniprot.org/citations/16443351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16443351 |
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