| http://purl.uniprot.org/citations/16443754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16443754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16443754 | http://www.w3.org/2000/01/rdf-schema#comment | "The type II alpha isoform of phosphatidylinositol 4-kinase has recently been shown to function in the recruitment of adaptor protein-1 complexes to the trans-Golgi network. Here we show that phosphatidylinositol 4-kinase IIalpha is also a component of highly dynamic membranes of the endosomal system where it colocalises with protein markers of the late endosome and with endocytosed epidermal growth factor. When phosphatidylinositol 4-kinase IIalpha activity was inhibited in vivo using the monoclonal antibody 4C5G or by depression of endogenous phosphatidylinositol 4-kinase IIalpha protein levels using RNA interference, ligand-bound epidermal growth factor receptor failed to traffic to late endosomes and instead accumulated in vesicles in a sub-plasma membrane compartment. Furthermore, lysosomal degradation of activated epidermal growth factor receptor was dramatically impaired in small inhibitory RNA-treated cells. We demonstrate that phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02752"xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02752"xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Berditchevski F."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Berditchevski F."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Hsuan J.J."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Hsuan J.J."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "De Matteis M.A."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "De Matteis M.A."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Stephens D.J."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Stephens D.J."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Minogue S."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Minogue S."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Waugh M.G."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/author | "Waugh M.G."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/pages | "571-581"xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/pages | "571-581"xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/title | "Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor."xsd:string |
| http://purl.uniprot.org/citations/16443754 | http://purl.uniprot.org/core/title | "Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor."xsd:string |