| http://purl.uniprot.org/citations/16444015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16444015 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated and characterized a nickel (Ni2+)-resistant mutant (GA1) of Schizosaccharomyces pombe. This mutant strain displayed resistance to both Ni2+ and Zn2+, but not to Cd2+, Co2+, and Cu2+. The growth rate of GA1 increased proportionally with increasing Mg2+ concentrations until 50 mM Mg2+. The GA1 mutation phenotype suggests a defect in Mg2+ uptake. Sequence analysis of the GA1 open reading frame (ORF) O13779, which is homologous to the prokaryotic and eukaryotic CorA Mg2+ transport systems, revealed a point mutation at codon 153 (ccc to acc) resulting in a Pro153Thr substitution in the N-terminus of the CorA domain. Our results provide novel genetic information about Ni2+ resistance in fission yeast. Specifically, that reducing Mg2+ influx through the CorA Mg2+ transport membrane protein confers Ni2+ resistance in S. pombe. We also report that Ni2+ ion detoxification of the fission yeast is related to histidine metabolism and pH."xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.org/dc/terms/identifier | "doi:10.1385/mb:32:2:139"xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/author | "Temizkan G."xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/author | "Akman G."xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/author | "Sarikaya A.T."xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/name | "Mol Biotechnol"xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/pages | "139-146"xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/title | "Nickel resistance in fission yeast associated with the magnesium transport system."xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/16444015 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16444015 |
| http://purl.uniprot.org/citations/16444015 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16444015 |
| http://purl.uniprot.org/uniprot/P36605#attribution-131938EBEC453642461B42985DCCC3E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16444015 |
| http://purl.uniprot.org/uniprot/O13779#attribution-131938EBEC453642461B42985DCCC3E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16444015 |
| http://purl.uniprot.org/uniprot/#_O13779-mappedCitation-16444015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16444015 |
| http://purl.uniprot.org/uniprot/#_P36605-mappedCitation-16444015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16444015 |
| http://purl.uniprot.org/uniprot/O13779 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16444015 |
| http://purl.uniprot.org/uniprot/P36605 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16444015 |