| http://purl.uniprot.org/citations/16444273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16444273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16444273 | http://www.w3.org/2000/01/rdf-schema#comment | "Human earwax consists of wet and dry types. Dry earwax is frequent in East Asians, whereas wet earwax is common in other populations. Here we show that a SNP, 538G --> A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. The AA genotype corresponds to dry earwax, and GA and GG to wet type. A 27-bp deletion in ABCC11 exon 29 was also found in a few individuals of Asian ancestry. A functional assay demonstrated that cells with allele A show a lower excretory activity for cGMP than those with allele G. The allele A frequency shows a north-south and east-west downward geographical gradient; worldwide, it is highest in Chinese and Koreans, and a common dry-type haplotype is retained among various ethnic populations. These suggest that the allele A arose in northeast Asia and thereafter spread through the world. The 538G --> A SNP is the first example of DNA polymorphism determining a visible genetic trait."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1733"xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1733"xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishikawa T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishikawa T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishida T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishida T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishibashi M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ishibashi M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nakashima M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nakashima M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Komatsu K."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Komatsu K."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nomura M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Nomura M."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |
| http://purl.uniprot.org/citations/16444273 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |