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http://purl.uniprot.org/citations/16446548http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

To detect new specific gene expressions in squamous cell carcinoma of the esophagus.

Methods

Representational difference analysis of cDNA (cDNA RDA) was applied to a human esophageal cancer cell line (KYSE170) and a human esophageal epithelial cell line (HEEC-1).

Results

LAGE-1 was expressed specifically in KYSE170, but not in HEEC-1. It is also expressed in 27% of esophageal cancer cell lines (3/11) and 33% of esophageal cancer tissues (10/30), but not in other HEECs, normal esophageal epithelium, or other normal tissues except testis, ovary and kidney. The expression of LAGE-1 is strongly correlated with that of MAGE-A1 (p = 0.013, Fisher's exact probability test). Fibronectin, cytokeratin 6B, cytokeratin 19, cyclin D2 and Ten-m2 were detected as candidates for downregulated genes. Reduced expression profiles of them were also identified using cDNA microarrays. The expression of LAGE-1 was induced by 5'-aza-2'-deoxycytidine (5Aza-dC) and trichostatin A (TSA) in esophageal cancer cell lines, which did not express LAGE-1. In HEECs, 5Aza-dC induced LAGE-1 expression, but TSA did not.

Conclusions

LAGE-1 expression was detected in esophageal cancer by cDNA RDA. LAGE-1 might have the potential to be a target antigen for anti-tumoral immunotherapy in esophageal cancers because of its tumor-specific expression similar to that of MAGE-A1."xsd:string
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http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Kondo K."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Shimada Y."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Yamasaki S."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Imamura M."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Kawabe A."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Meltzer S.J."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Kan T."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Kaganoi J."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/author"Teratani N."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/name"Oncology"xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/pages"25-33"xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/title"A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray."xsd:string
http://purl.uniprot.org/citations/16446548http://purl.uniprot.org/core/volume"70"xsd:string
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