| http://purl.uniprot.org/citations/16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16449227 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite intensive research over the last two decades, there are still no specific markers of endogenous lipid hydroperoxide-mediated DNA damage. We recently demonstrated that heptanone-etheno-2'-deoxyguanosine adducts are formed in the DNA of rat intestinal epithelial cells that stably express cyclooxygenase-2. Heptanone-etheno adducts can only arise from the reaction of lipid hydroperoxide-derived 4-oxo-2(E)-nonenal with DNA. This raised the possibility that similar adducts would be formed in vivo in settings where cyclooxygenase-2 expression is increased. Therefore, DNA-adduct formation was studied in C57BL/6JAPC(min) mice, a colorectal cancer mouse model in which cyclooxygenase-2 is up-regulated. 15(S)-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid is the major lipid hydroperoxide produced endogenously by cyclooxygenase-2. It undergoes homolytic decomposition to the DNA-reactive bifunctional electrophile 4-oxo-2(E)-nonenal, which forms heptanone-etheno adducts with DNA. A quantitative comparison was made of the heptanone-etheno-DNA adducts present in C57BL/6J and C57BL/6JAPC(min) mice. Using highly specific and sensitive methodology based on stable isotope dilution liquid chromatography/tandem mass spectrometry, we have detected the endogenous formation of heptanone-etheno adducts in mammalian tissue DNA for the first time. In addition, we found that there were statistically significant increased levels of the heptanone-etheno-2'-deoxyguanosine and heptanone-etheno-2'-deoxycytidine adducts in the C57BL/6JAPC(min) mice when compared with the control C57BL/6J mice."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m600178200"xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/author | "Blair I.A."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/author | "Pollack M."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/author | "Williams M.V."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/pages | "10127-10133"xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/title | "Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice."xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16449227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16449227 |
| http://purl.uniprot.org/citations/16449227 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16449227 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_E9Q4H1-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_F6Q4R2-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_Q8BRD8-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_Q3UQT2-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_Q8BNP7-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_Q61315-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |
| http://purl.uniprot.org/uniprot/#_Q8C493-mappedCitation-16449227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16449227 |