http://purl.uniprot.org/citations/16450370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16450370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16450370 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveThe UCHL-1 gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association.MethodsIn a new large case-control study in white individuals (3,023 subjects), the S18Y variant was not protective against PD under any genetic model of inheritance. Similarly, a more powerful haplotype-tagging approach did not detect other associated variants.ResultsFinally, in an updated S18Y-PD meta-analysis (6,594 subjects), no significant association was observed under additive, recessive, or dominant models (odds ratio = 1.00 [95% confidence interval: 0.74-1.33]; odds ratio = 1.01 [95% confidence interval: 0.76-1.35]; and odds ratio = 0.96 [95% confidence interval: 0.86-1.08], respectively), and a cumulative meta-analysis showed a trend toward a null effect.InterpretationBased on the current evidence, the UCHL-1 gene does not exhibit a protective effect in PD."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.org/dc/terms/identifier | "doi:10.1002/ana.20757"xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.org/dc/terms/identifier | "doi:10.1002/ana.20757"xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Casas J.P."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Casas J.P."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Barker R."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Barker R."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Goldstein D.B."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Goldstein D.B."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Bhatia K.P."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Bhatia K.P."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Wood N.W."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Wood N.W."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Gandhi S."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Gandhi S."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Lynch T."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Lynch T."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Holton J.L."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Holton J.L."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Gibson J.M."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Gibson J.M."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Revesz T."xsd:string |
http://purl.uniprot.org/citations/16450370 | http://purl.uniprot.org/core/author | "Revesz T."xsd:string |