| http://purl.uniprot.org/citations/16452633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16452633 | http://www.w3.org/2000/01/rdf-schema#comment | "Gcs1 is an Arf GTPase-activating protein (Arf-GAP) that mediates Golgi-ER and post-Golgi vesicle transport in yeast. Here we show that the Snc1,2 v-SNAREs, which mediate endocytosis and exocytosis, interact physically and genetically with Gcs1. Moreover, Gcs1 and the Snc v-SNAREs colocalize to subcellular structures that correspond to the trans-Golgi and endosomal compartments. Studies performed in vitro demonstrate that the Snc-Gcs1 interaction results in the efficient binding of recombinant Arf1Delta17N-Q71L to the v-SNARE and the recruitment of purified coatomer. In contrast, the presence of Snc had no effect on Gcs1 Arf-GAP activity in vitro, suggesting that v-SNARE binding does not attenuate Arf1 function. Disruption of both the SNC and GCS1 genes results in synthetic lethality, whereas overexpression of either SNC gene inhibits the growth of a distinct subset of COPI mutants. We show that GFP-Snc1 recycling to the trans-Golgi is impaired in gcs1Delta cells and these COPI mutants. Together, these results suggest that Gcs1 facilitates the incorporation of the Snc v-SNAREs into COPI recycling vesicles and subsequent endosome-Golgi sorting in yeast."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-09-0832"xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Spang A."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Robinson M."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Schindler C."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Gerst J.E."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Kama R."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Gabriely G."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Johnston G.C."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Poon P.P."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Singer R.A."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/author | "Murray L.E."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/pages | "1845-1858"xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/title | "The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeast."xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/16452633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16452633 |
| http://purl.uniprot.org/citations/16452633 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16452633 |
| http://purl.uniprot.org/uniprot/P35197#attribution-D9BB12827BA59F4AA5F5EA4FBC86A6BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16452633 |
| http://purl.uniprot.org/uniprot/P31109#attribution-D9BB12827BA59F4AA5F5EA4FBC86A6BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16452633 |
| http://purl.uniprot.org/uniprot/P33328#attribution-D9BB12827BA59F4AA5F5EA4FBC86A6BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16452633 |
| http://purl.uniprot.org/uniprot/#_P31109-mappedCitation-16452633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16452633 |
| http://purl.uniprot.org/uniprot/#_P33328-mappedCitation-16452633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16452633 |