| http://purl.uniprot.org/citations/16453260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16453260 | http://www.w3.org/2000/01/rdf-schema#comment | "To elucidate the contribution of human leukocyte antigen (HLA) haplotypes and their genotypic combinations to immune status after measles-mumps-rubella (MMR) vaccination, 346 children 12-18 years of age were studied. The class I A*29-Cw*16-B*44 haplotype was associated with lower levels of immunoglobulin G (IgG) antibody to both measles (P=.08) and mumps (P=.03) viral antigens. The A*26-Cw*12-B*38 haplotype was associated with higher cellular immune responses to measles (P=.02) and mumps (P=.01) vaccine viruses. Subjects with the class II DRB1*03-DQB1*02-DPB1*04 haplotype had higher lymphoproliferative responses to measles virus (P=.01) and mumps virus (P=.006). The DRB1*15/16-DQB1*06-DPB1*03 haplotype was associated with high levels of IgG antibody to measles virus (P=.09) but low levels of IgG antibody to rubella virus (P=.02), whereas DRB1*04-DQB1*03-DPB1*03 was associated with high lymphoproliferative responses to both measles (P=.01) and rubella (P=.002) vaccine viruses. A*26-Cw*12-B*38 was associated with both mumps virus-specific humoral (P=.007) and cell-mediated (P=.01) immune responses after 2 doses of MMR vaccine. Haplotype DRB1*04-DQB1*03-DPB1*03 was associated with both lower rubella virus IgG antibody levels (P=.02) and higher rubella virus-specific lymphoproliferation (P=.002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.org/dc/terms/identifier | "doi:10.1086/500144"xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/author | "Pankratz V.S."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/author | "Jacobson R.M."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/author | "Ovsyannikova I.G."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/author | "Poland G.A."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/author | "Vierkant R.A."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/pages | "655-663"xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/title | "Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine."xsd:string |
| http://purl.uniprot.org/citations/16453260 | http://purl.uniprot.org/core/volume | "193"xsd:string |
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