http://purl.uniprot.org/citations/16455072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16455072 | http://www.w3.org/2000/01/rdf-schema#comment | "We used muscarinic M2 and M4 receptor knockout (KO) mice to further explore the role of the cholinergic system in anxiety. Using the shock-probe burying model we were able to both assess anxiety and cognition. In this paradigm, an anxiolytic response is reflected by decreased burying behavior. In addition, retention latency depicts long-term memory performance. Whereas muscarinic M2 receptor KO mice did not differ behaviorally from wild-type mice, muscarinic M4 receptor KO mice showed increased anxiolysis, but normal long-term memory compared to wild-type mice. Therefore, muscarinic M4 receptors are of particular significance in anxiety modulation that seems dissociated from changes in long-term memory."xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2005.12.036"xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/author | "Nomikos G.G."xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/author | "Degroot A."xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/pages | "183-186"xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/title | "Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model."xsd:string |
http://purl.uniprot.org/citations/16455072 | http://purl.uniprot.org/core/volume | "531"xsd:string |
http://purl.uniprot.org/citations/16455072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16455072 |
http://purl.uniprot.org/citations/16455072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16455072 |
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http://purl.uniprot.org/uniprot/Q05CZ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16455072 |