| http://purl.uniprot.org/citations/16455487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16455487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16455487 | http://www.w3.org/2000/01/rdf-schema#comment | "Many disease states result from gene overexpression, often in a specific genetic context. To explore gene overexpression phenotypes systematically, we assembled an array of 5280 yeast strains, each containing an inducible copy of an S. cerevisiae gene, covering >80% of the genome. Approximately 15% of the overexpressed genes (769) reduced growth rate. This gene set was enriched for cell cycle-regulated genes, signaling molecules, and transcription factors. Overexpression of most toxic genes resulted in phenotypes different from known deletion mutant phenotypes, suggesting that overexpression phenotypes usually reflect a specific regulatory imbalance rather than disruption of protein complex stoichiometry. Global overexpression effects were also assayed in the context of a cyclin-dependent kinase mutant (pho85Delta). The resultant gene set was enriched for Pho85p targets and identified the yeast calcineurin-responsive transcription factor Crz1p as a substrate. Large-scale application of this approach should provide a strategy for identifying target molecules regulated by specific signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.12.011"xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.12.011"xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Snyder M."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Snyder M."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Hughes T.R."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Hughes T.R."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Oliver S.G."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Oliver S.G."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Boone C."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Boone C."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Andrews B.J."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Andrews B.J."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Papp B."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Papp B."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Chua G."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Chua G."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Cyert M."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Cyert M."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Kafadar K."xsd:string |
| http://purl.uniprot.org/citations/16455487 | http://purl.uniprot.org/core/author | "Kafadar K."xsd:string |