| http://purl.uniprot.org/citations/16456002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16456002 | http://www.w3.org/2000/01/rdf-schema#comment | "The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a central role in T cell activation and T cell development. SLP-76 has three functional modules: an acidic domain with three key tyrosines, a central proline-rich domain, and a C-terminal Src homology 2 domain. Of these, mutation of the three N-terminal tyrosines (Y112, Y128, and Y145) results in the most profound effects on T cell development and function. Y112 and Y128 associate with Vav and Nck, two proteins shown to be important for TCR-induced phosphorylation of proximal signaling substrates, Ca(2+) flux, and actin reorganization. Y145 has been shown to be important for optimal association of SLP-76 with inducible tyrosine kinase, a key regulator of T cell function. To investigate further the role of the phosphorylatable tyrosines of SLP-76 in TCR signaling, cell lines and primary T cells expressing SLP-76 with mutations in individual or paired tyrosine residues were analyzed. These studies show that Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.4.2430"xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Sadler J."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Jordan M.S."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Koretzky G.A."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Singer A.L."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Finkelstein L.D."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/author | "Austin J.E."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/pages | "2430-2438"xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/title | "Functional hierarchy of the N-terminal tyrosines of SLP-76."xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16456002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16456002 |
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