| http://purl.uniprot.org/citations/16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16456668 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-traumatic inflammation response has been implicated in secondary injury mechanisms after spinal cord injury (SCI). Interleukin-1 (IL-1) is a key inflammatory mediator that is increasingly expressed after SCI. The action of IL-1 is mediated through its functional receptor, type I interleukin-1 receptor (IL-1RI). However, whether this receptor is expressed after SCI remains to be elucidated. In the present study, the temporospatial expression of IL-1RI was detected in rats that received a moderate contusive SCI (a 10 g rod dropped at a height of 12.5 mm) at the ninth to tenth thoracic vertebral level using a widely used New York University impact device. Our study demonstrated that IL-1RI was slightly increased at 4 h post-injury compared to the normal or sham-operated controls, reached the peak at 8 h at mRNA level (4.44-fold, P<0.01) and 1 d at protein level (2.62-fold, P<0.01). IL-1RI remained at its elevated levels for a relatively long duration (4 h-7 days). Spatially, IL-1RI was observed throughout the entire length of a 10 mm-long cord segment containing the injury epicenter. Colocalization of IL-1RI was found in neurons, oligodendrocytes, astrocytes, and activated microglia. Our results suggest that the elevated expression of IL-1RI after SCI may contribute to posttraumatic inflammation responses of IL-1."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00401-005-0016-x"xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Xu X.M."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Wang X.F."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Huang L.D."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Hu J.G."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Lu P.H."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/author | "Yu P.P."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/name | "Acta Neuropathol"xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/pages | "220-228"xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/title | "Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats."xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/16456668 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16456668 |
| http://purl.uniprot.org/citations/16456668 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16456668 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K6N4-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A0A0G2KAJ2-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A0A8I6G672-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AFI3-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A6INM9-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A6INN0-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |
| http://purl.uniprot.org/uniprot/#_A6INN1-mappedCitation-16456668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16456668 |