| http://purl.uniprot.org/citations/16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16458078 | http://www.w3.org/2000/01/rdf-schema#comment | "ABC transporters pump out from cells a large number of endo- and xenobiotics including signal molecules and toxins; they are molecular markers of stem/progenitor cells as well. Here, we present the study of temporal/spatial patterns of Abcb1 isoforms and Abcg2 transporter expression and efflux activity in pre- and early postimplantation murine embryos. We found in 2-cell embryos abcb1a, abcb1b and abcg2 mRNAs which were believed to be maternally inherited. The expression of abcb1b and abcg2 genes was found in blastocysts and in 7 days postcoitum (dpc) embryos, while in 9dpc embryos beside of abcb1b/abcg2, the abcb1a gene was expressed. The abcb2 mRNA was detectable neither in pre-nor in postimplantation embryos. Moreover, we analysed temporal/spatial patterns of rhodamine 123/Hoechst 33342 efflux, which mirrors the ABC transporter phenotype, from individual cells of pre- and postimplantation murine embryos. The blastomeres of 2-, 4- and 8-cell embryos had efflux-inactive phenotype. Single, efflux-active cells emerged first in the morulae and their number increased in blastocyst inner cell mass. In 6 and 7 dpc embryos, all embryonic cells hold the efflux-active phenotype. Proximal embryonic endoderm of 6-8 dpc embryos contained two sub-domains: one consisted of efflux-active cells and another one of efflux-inactive cells reflecting polarity of an embryo. Between 7 and 8 dpc, at the onset of organogenesis, the vehement surge of efflux-inactive embryonic cells occurred, and their number increased in 9 dpc embryos, which consequently contained few efflux-active cells."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.modgep.2005.12.003"xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Kujawa M."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Jankowska-Steifer E."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Kowalewski C."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Hyc A."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Mystkowska E.T."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/author | "Sawicki W.T."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/name | "Gene Expr Patterns"xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/pages | "738-746"xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/title | "Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development."xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16458078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16458078 |
| http://purl.uniprot.org/citations/16458078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16458078 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDM4-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGL4-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B6-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWA2-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_D3YVG8-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_D3Z150-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_E0CY02-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_E0CYI8-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF49-mappedCitation-16458078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458078 |