| http://purl.uniprot.org/citations/16458123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16458123 | http://www.w3.org/2000/01/rdf-schema#comment | "2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), one of the most abundant carcinogenic heterocyclic amines in cooked foods, is speculated to be a human liver carcinogen. To test the hypothesis that it is metabolically activated by CYP1A2, we here investigated the effects of caffeine as a CYP1A2 inducer on MeIQx induced rat hepatocarcinogenesis in a medium-term liver bioassay system. Unexpectedly, no modifying effects of caffeine on MeIQx-induced hepatocarcinogenesis were evident, although up-regulation of CYP1A2 and NAT2 were detected. Therefore, mRNAs extracted from GST-P positive foci and the surrounding liver tissue in each group were analyzed to explore mechanisms in detail. The results suggest that suppression of syndecan-2 (Sdc2) and induction of cell cycle arrest through a p21-dependent pathway might have counter-acted any promotion effects of up-regulation of CYP1A2."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2005.02.041"xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Ogawa K."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Suzuki S."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Shirai T."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Kuribayashi M."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Asamoto M."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/author | "Hokaiwado N."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/pages | "289-299"xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/title | "Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences."xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://purl.uniprot.org/core/volume | "232"xsd:string |
| http://purl.uniprot.org/citations/16458123 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16458123 |
| http://purl.uniprot.org/citations/16458123 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16458123 |
| http://purl.uniprot.org/uniprot/P34900#attribution-5E5D5356088E9FA3B3AAD86086F0404C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/#_A0A8I6ASG6-mappedCitation-16458123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/#_A0A8I6B5M9-mappedCitation-16458123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/#_P34900-mappedCitation-16458123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/#_Q6IRK3-mappedCitation-16458123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/P34900 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16458123 |
| http://purl.uniprot.org/uniprot/Q6IRK3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16458123 |
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