| http://purl.uniprot.org/citations/16458338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16458338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16458338 | http://www.w3.org/2000/01/rdf-schema#comment | "The major lethal toxins present in the venoms of the red-headed krait, Bungarus flaviceps, and the Malayan krait, Bungarus candidus, have both been purified. Each consists of two polypeptide chains, A and B, joined by a disulfide bond. In the present study, primary structures of these toxins were determined by Edman degradation and by nucleotide sequencing of the cDNA clones. Amino acid sequencing of the N-terminus and enzymatically digested peptides revealed that the A and B chains were highly homologous to those of beta-bungarotoxins (beta-Bgts) from Bungarus multicinctus, respectively. We isolated cDNA clones encoding the A and B chains from both B. flaviceps and B. candidus venom gland cDNA libraries using probes designed based on the cDNA sequence of beta-Bgt from B. multicinctus. Two isoforms of the A chain and one isoform of the B chain were obtained from B. flaviceps, and one isoform of the A chain and two isoforms of the B chain were obtained from B. candidus. Both of the two A chains from B. flaviceps are made up of 119 amino acids and comprise 15 cysteine residues, while the A chains of beta-Bgt from other Bungarus species including B. candidus comprise 13 cysteine residues. The B chains from both species are composed of 59 amino acid residues and comprise seven cysteines. In conclusion, the lethal toxin from B. flaviceps is considered to be a novel isoform of beta-Bgt, which has a different pattern of cysteine residues from known beta-Bgts."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2005.12.004"xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2005.12.004"xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Chanhome L."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Chanhome L."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Higuchi S."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Higuchi S."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Murayama N."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Murayama N."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Ogawa Y."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Ogawa Y."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Omori-Satoh T."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Omori-Satoh T."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Samejima Y."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Samejima Y."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Yanoshita R."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Yanoshita R."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Saguchi K."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Saguchi K."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Khow O."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Khow O."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Sitprija V."xsd:string |
| http://purl.uniprot.org/citations/16458338 | http://purl.uniprot.org/core/author | "Sitprija V."xsd:string |