| http://purl.uniprot.org/citations/16461359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16461359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16461359 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyglutamine diseases are inherited neurodegenerative diseases caused by the expanded polyglutamine proteins (polyQs). We have identified a novel guanosine triphosphatase (GTPase) named CRAG that contains a nuclear localization signal (NLS) sequence and forms nuclear inclusions in response to stress. After ultraviolet irradiation, CRAG interacted with and induced an enlarged ring-like structure of promyelocytic leukemia protein (PML) body in a GTPase-dependent manner. Reactive oxygen species (ROS) generated by polyQ accumulation triggered the association of CRAG with polyQ and the nuclear translocation of the CRAG-polyQ complex. Furthermore, CRAG promoted the degradation of polyQ at PML/CRAG bodies through the ubiquitin-proteasome pathway. CRAG knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. We propose that CRAG is a modulator of PML function and dynamics in ROS signaling and is protectively involved in the pathogenesis of polyglutamine diseases."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200505079"xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200505079"xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yoshizawa T."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yoshizawa T."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yamamura H."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yanagi S."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Yanagi S."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Hotta A."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Hotta A."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Inatome R."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Inatome R."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Qin Q."xsd:string |
| http://purl.uniprot.org/citations/16461359 | http://purl.uniprot.org/core/author | "Qin Q."xsd:string |