| http://purl.uniprot.org/citations/16467200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16467200 | http://www.w3.org/2000/01/rdf-schema#comment | "The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive target for drug development. We report here a novel and highly specific anti-FGFR3-neutralizing antibody (PRO-001). PRO-001 binds to FGFR3 expressed on transformed cells and inhibits FGFR3 autophosphorylation and downstream signaling. The antibody inhibited the growth of FGFR3-expressing FDCP cells (IC(50) of 0.5 microg/mL) but not that of cells expressing FGFR1 or FGFR2, and potently inhibited FGFR3-dependent solid tumor growth in a mouse xenograft model. Furthermore, PRO-001 inhibited the growth of the FGFR3-expressing, human myeloma cell line, UTMC2. Inhibition of viability was still observed when cells were cocultured with stroma or in the presence of IL-6 or IGF-1. PRO-001 did not inhibit constitutive activation of K650E, G384D, and Y373C FGFR3 in myeloma cell lines and failed to inhibit the growth of these cells. Most importantly, however, PRO-001 induced cytotoxic responses in primary t(4;14)(+) MM samples with an increase in apoptotic index of 20% to 80% as determined by annexin V staining. The data demonstrate that PRO-001 is a potent and specific inhibitor of FGFR3 and deserves further study for the treatment of FGFR3-expressing myeloma."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-10-4179"xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Chang H."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Stewart A.K."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Wei E."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Chumakov I."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Singer Y."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Trudel S."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Rom E."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Yayon A."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Li Z.H."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Liang S.B."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/author | "Kotzer S."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/pages | "4039-4046"xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/title | "The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells."xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/16467200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16467200 |
| http://purl.uniprot.org/citations/16467200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16467200 |
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| http://purl.uniprot.org/uniprot/#_A0A3S5WLI4-mappedCitation-16467200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16467200 |
| http://purl.uniprot.org/uniprot/#_A0A3S5XAL5-mappedCitation-16467200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16467200 |
| http://purl.uniprot.org/uniprot/#_A0N9W0-mappedCitation-16467200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16467200 |