| http://purl.uniprot.org/citations/16469704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16469704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16469704 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated intramembrane proteolysis (RIP) of endoplasmic reticulum (ER) membrane-anchored transcription factors is known to maintain sterol homeostasis and to mediate the unfolded protein response (UPR). Here, we identified CREBH as a RIP-regulated liver-specific transcription factor that is cleaved upon ER stress and required to activate expression of acute phase response (APR) genes. Proinflammatory cytokines increase expression of ER membrane-anchored CREBH. In response to ER stress, CREBH is cleaved by site-1 and site-2 proteases to liberate an amino-terminal fragment that transits to the nucleus to activate transcription of the genes encoding serum amyloid P-component (SAP) and C-reactive protein (CRP). Proinflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver in vivo. Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.11.040"xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.11.040"xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Sakaki K."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Sakaki K."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Kaufman R.J."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Kaufman R.J."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Back S.H."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Back S.H."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Rutkowski D.T."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Rutkowski D.T."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Saunders T."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/author | "Saunders T."xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16469704 | http://purl.uniprot.org/core/name | "Cell"xsd:string |