| http://purl.uniprot.org/citations/16469876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16469876 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hoxa9 and Meis1 genes represent important oncogenic collaborators activated in a significant proportion of human leukemias with genetic alterations in the MLL gene. In this study, we show that the transforming property of Meis1 is modulated by 3 conserved domains, namely the Pbx interaction motif (PIM), the homeodomain, and the C-terminal region recently described to possess transactivating properties. Meis1 and Pbx1 interaction domain-swapping mutants are dysfunctional separately, but restore the full oncogenic activity of Meis1 when cotransduced in primary cells engineered to overexpress Hoxa9, thus implying a modular nature for PIM in Meis1-accelerated transformation. Moreover, we show that the transactivating domain of VP16 can restore, and even enhance, the oncogenic potential of the Meis1 mutant lacking the C-terminal 49 amino acids. In contrast to Meis1, the fusion VP16-Meis1 is spontaneously oncogenic, and all leukemias harbor genetic activation of endogenous Hoxa9 and/or Hoxa7, suggesting that Hoxa gene activation represents a key event required for the oncogenic activity of VP16-Meis1."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-06-2244"xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Girard S."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Sauvageau G."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Featherstone M."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Mamo A."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Beslu N."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Bijl J."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Mayotte N."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Kroon E."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Krosl J."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/author | "Bisaillon R."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/pages | "622-629"xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/title | "Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation."xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16469876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16469876 |
| http://purl.uniprot.org/citations/16469876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16469876 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQB8-mappedCitation-16469876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16469876 |
| http://purl.uniprot.org/uniprot/#_H3BLB6-mappedCitation-16469876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16469876 |
| http://purl.uniprot.org/uniprot/#_Q3UJ00-mappedCitation-16469876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16469876 |
| http://purl.uniprot.org/uniprot/#_P09631-mappedCitation-16469876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16469876 |