| http://purl.uniprot.org/citations/16469929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16469929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16469929 | http://www.w3.org/2000/01/rdf-schema#comment | "Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1120541"xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1120541"xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Joukov V."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Joukov V."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Luger K."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Luger K."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Barbera A.J."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Barbera A.J."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Chodaparambil J.V."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Chodaparambil J.V."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Kaye K.M."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Kaye K.M."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Kelley-Clarke B."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Kelley-Clarke B."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Walter J.C."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/author | "Walter J.C."xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/pages | "856-861"xsd:string |
| http://purl.uniprot.org/citations/16469929 | http://purl.uniprot.org/core/pages | "856-861"xsd:string |