| http://purl.uniprot.org/citations/16472744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16472744 | http://www.w3.org/2000/01/rdf-schema#comment | "Coiled-coil sequences in proteins commonly share a seven-amino acid repeat with nonpolar side chains at the first (a) and fourth (d) positions. We investigate here the role of a 3-3-1 hydrophobic repeat containing nonpolar amino acids at the a, d, and g positions in determining the structures of coiled coils using mutants of the GCN4 leucine zipper dimerization domain. When three charged residues at the g positions in the parental sequence are replaced by nonpolar alanine or valine side chains, stable four-helix structures result. The X-ray crystal structures of the tetramers reveal antiparallel, four-stranded coiled coils in which the a, d, and g side chains interlock in a combination of knobs-into-knobs and knobs-into-holes packing. Interfacial interactions in a coiled coil can therefore be prescribed by hydrophobic-polar patterns beyond the canonical 3-4 heptad repeat. The results suggest that the conserved, charged residues at the g positions in the GCN4 leucine zipper can impart a negative design element to disfavor thermodynamically more stable, antiparallel tetramers."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2005.10.010"xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Lu M."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Kallenbach N.R."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/author | "Eliezer D."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/pages | "247-255"xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/title | "Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat."xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/16472744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16472744 |
| http://purl.uniprot.org/citations/16472744 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16472744 |
| http://purl.uniprot.org/uniprot/P03069#attribution-430ADE64D848FADACD52FB49EAC43B34 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16472744 |
| http://purl.uniprot.org/uniprot/#_P03069-mappedCitation-16472744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16472744 |
| http://purl.uniprot.org/uniprot/P03069 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16472744 |