| http://purl.uniprot.org/citations/16473593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16473593 | http://www.w3.org/2000/01/rdf-schema#comment | "Alsin is the gene product mutated in three juvenile-onset neurodegenerative disorders including amyotrophic lateral sclerosis 2 (ALS2). Sequence motif searches within Alsin predict the presence of Vps9, DH, and PH domains, implying that Alsin may function as a guanine nucleotide exchange factor (GEF) for Rab5 and a member of the Rho GTPase family. Procedures are presented in this chapter for the expression, purification, and biochemical characterization of the individual GEF domains of Alsin. A fractionation method is also described for the determination of Alsin's subcellular distribution. The presence of both Rac1 and Rab5 GEF activities makes Alsin a unique dual exchange factor that may couple endocytosis (via Rab5 activation) to cytoskeletal modulation (via Rac1 activation)."xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0076-6879(05)03022-3"xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/author | "Horazdovsky B.F."xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/author | "Topp J.D."xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/author | "Carney D.S."xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/name | "Methods Enzymol"xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/pages | "261-276"xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/title | "Biochemical characterization of Alsin, a Rab5 and Rac1 guanine nucleotide exchange factor."xsd:string |
| http://purl.uniprot.org/citations/16473593 | http://purl.uniprot.org/core/volume | "403"xsd:string |
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