| http://purl.uniprot.org/citations/16473882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16473882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16473882 | http://www.w3.org/2000/01/rdf-schema#comment | "Classic major histocompatibility complex (MHC) proteins associate with antigen- and self-derived peptides in an allele-specific manner. Herein we present the crystal structure of the MHC class I protein H-2K(d) (K(d)) expressed by BALB/c mice in complex with an antigenic peptide derived from influenza A/PR/8/34 nucleoprotein (Flu, residues 147-155, TYQRTRALV). Analysis of our structure in conjunction with the sequences of naturally processed epitopes provides a comprehensive understanding of the dominant K(d) peptide-binding motif. We find that Flu residues Tyr(P2), Thr(P5), and Val(P9) are sequestered into the B, C, and F pockets of the K(d) groove, respectively. The shape and chemistry of the polymorphic B pocket make it an optimal binding site for the side chain of Tyr(P2) as the dominant anchoring residue of nonameric peptides. The non-polar F pocket limits the amino acid repertoire at P9 to hydrophobic residues such as Ile, Leu, or Val, whereas the C pocket restricts the size of the P5-anchoring side chain. We also show that Flu is accommodated in the complex through an unfavorable kink in the otherwise extended peptide backbone due to the presence of a prominent ridge in the K(d) groove. Surprisingly, this backbone conformation is strikingly similar to D(b)-presented peptides despite the fact that these proteins employ distinct motif-anchoring strategies. The results presented in this study provide a solid foundation for the understanding of K(d)-restricted antigen presentation and recognition events."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M510511200"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m510511200"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/author | "Mitaksov V."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/author | "Mitaksov V."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/pages | "10618-10625"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/pages | "10618-10625"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/title | "Structural definition of the H-2Kd peptide-binding motif."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/title | "Structural definition of the H-2Kd peptide-binding motif."xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16473882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16473882 |
| http://purl.uniprot.org/citations/16473882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16473882 |
| http://purl.uniprot.org/citations/16473882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16473882 |
| http://purl.uniprot.org/citations/16473882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16473882 |
| http://purl.uniprot.org/uniprot/Q701N7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16473882 |
| http://purl.uniprot.org/uniprot/#_Q701N7-citation-16473882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16473882 |