| http://purl.uniprot.org/citations/16476743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16476743 | http://www.w3.org/2000/01/rdf-schema#comment | "To examine whether globotriaosylceramide (Gb3/CD77) is a receptor for verotoxins (VTs) in vivo, sensitivity of Gb3/CD77 synthase null mutant mice to VT-2 and VT-1 was analyzed. Although wild-type mice died after administration of 0.02 microg of VT-2 or 1.0 microg of VT-1, the mutant mice showed no reaction to doses as much as 100 times that administered to wild types. Expression analysis of Gb3/CD77 in mouse tissues with antibody revealed that low, but definite, levels of Gb3/CD77 were expressed in the microvascular endothelial cells of the brain cortex and pia mater and in renal tubular capillaries. Corresponding to the Gb3/CD77 expression, tissue damage with edema, congestion, and cytopathic changes was observed, indicating that Gb3/CD77 (and its derivatives) exclusively function as a receptor for VTs in vivo. The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m600057200"xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Numata S."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Ohta M."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Furukawa K.'"xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Wiels J."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Okuda T."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Kawamura K."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Tokuda N."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/author | "Tajima O."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/pages | "10230-10235"xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/title | "Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins."xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16476743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16476743 |
| http://purl.uniprot.org/citations/16476743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16476743 |
| http://purl.uniprot.org/uniprot/Q67BJ4#attribution-383B89432CB7F22F533791B495C82760 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16476743 |
| http://purl.uniprot.org/uniprot/Q67BJ4#attribution-5E45BC0429627A1DD9426F2D685BFD44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16476743 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI36-mappedCitation-16476743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16476743 |
| http://purl.uniprot.org/uniprot/#_Q67BJ4-mappedCitation-16476743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16476743 |