| http://purl.uniprot.org/citations/16479000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16479000 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase C theta (PKC theta) is unique among PKC isozymes in its translocation to the center of the immune synapse in T cells and its unique downstream signaling. Here we show that the hematopoietic protein tyrosine phosphatase (HePTP) also accumulates in the immune synapse in a PKC theta-dependent manner upon antigen recognition by T cells and is phosphorylated by PKC theta at Ser-225, which is required for lipid raft translocation. Immune synapse translocation was completely absent in antigen-specific T cells from PKC theta-/-mice. In intact T cells, HePTP-S225A enhanced T-cell receptor (TCR)-induced NFAT/AP-1 transactivation, while the acidic substitution mutant was as efficient as wild-type HePTP. We conclude that HePTP is phosphorylated in the immune synapse by PKC theta and thereby targeted to lipid rafts to temper TCR signaling. This represents a novel mechanism for the active immune synapse recruitment and activation of a phosphatase in TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.5.1806-1816.2006"xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Williams S."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Baier G."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Charvet C."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Mustelin T."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Rahmouni S."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Bottini N."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Tautz L."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Nika K."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Bruckner S."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/author | "Schoenberger S.P."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/pages | "1806-1816"xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/title | "Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16479000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16479000 |
| http://purl.uniprot.org/citations/16479000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16479000 |
| http://purl.uniprot.org/uniprot/#_A6H667-mappedCitation-16479000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16479000 |
| http://purl.uniprot.org/uniprot/#_F8WGT6-mappedCitation-16479000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16479000 |
| http://purl.uniprot.org/uniprot/#_Q02111-mappedCitation-16479000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16479000 |
| http://purl.uniprot.org/uniprot/#_Q8CAV6-mappedCitation-16479000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16479000 |