| http://purl.uniprot.org/citations/16479074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16479074 | http://www.w3.org/2000/01/rdf-schema#comment | "The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes. In normal rat chondrocytes, we observed relatively high levels of Cav-3 and a very low level of COX-2 mRNA and protein. Upon treating the chondrocytes with 5 microM of CdCl(2) (Cd) for 6 hr, the expressions of COX-2 mRNA and protein were increased with the decreased Cav-3 mRNA and protein expressions. The detergent insoluble caveolae-rich membranous fractions that were isolated from the rat chondrocytes and treated with Cd contained the both proteins of both COX-2 and Cav-3 in a same fraction. The immuno-precipitation experiments showed complex formation between the COX-2 and Cav-3 in the rat chondrocytes. Purified COX-2 with glutathione S-transferase-fused COX-2 also showed complex formation with Cav-3. Confocal and electron microscopy also demonstrated the co-localization of COX-2 and Cav-3 in the plasma membrane. The results from our current study show that COX-2 and Cav-3 are co-localized in the caveolae of the plasma membrane, and they form a protein-protein complex. The co-localization of COX-2 with Cav-3 in the caveolae suggests that the caveolins might play an important role for regulating the function of COX-2."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.org/dc/terms/identifier | "doi:10.3346/jkms.2006.21.1.100"xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Cha S.H."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Jung S.M."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Lee W.K."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Oh K.J."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Kim H.W."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Jung S.Y."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Kwak J.O."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/author | "Huh Y.H."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/name | "J Korean Med Sci"xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/pages | "100-106"xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/title | "Evidence for cyclooxygenase-2 association with caveolin-3 in primary cultured rat chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/16479074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16479074 |
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