| http://purl.uniprot.org/citations/1648176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1648176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1648176 | http://www.w3.org/2000/01/rdf-schema#comment | "Kainic acid is a potent neurotoxin for certain neurons. Its neurotoxicity is thought to be mediated by an excitatory amino-acid-gated ion channel (ionotropic receptor) possessing nanomolar affinity for kainate. Here we describe a new member of the rat excitatory amino-acid receptor gene family, KA-1, that has a 30% sequence similarity with the previously characterized alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunits GluR-A to -D. The pharmacological profile of expressed recombinant KA-1 determined in binding experiments with [3H]kainate is different from that of the cloned AMPA receptors and similar to the mammalian high-affinity kainate receptor (kainate greater than quisqualate greater than glutamate much greater than AMPA) with a dissociation constant of about 5 nM for kainate. The selectively high expression of KA-1 messenger RNA in the CA3 region of the hippocampus closely corresponds to autoradiographically located high-affinity kainate binding sites. This correlation, as well as the particular in vivo pattern of neurodegeneration observed on kainate-induced neurotoxicity, suggests that KA-1 participates in receptors mediating the kainate sensitivity of neurons in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.org/dc/terms/identifier | "doi:10.1038/351742a0"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.org/dc/terms/identifier | "doi:10.1038/351742a0"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Werner P."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Werner P."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Seeburg P.H."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Seeburg P.H."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Wisden W."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Wisden W."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Voigt M."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Voigt M."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Keinaenen K."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/author | "Keinaenen K."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/pages | "742-744"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/pages | "742-744"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/title | "Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/title | "Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells."xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/volume | "351"xsd:string |
| http://purl.uniprot.org/citations/1648176 | http://purl.uniprot.org/core/volume | "351"xsd:string |