| http://purl.uniprot.org/citations/1648233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1648233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1648233 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a cDNA encoding a third type of protein-tyrosine-phosphatase. We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG. Northern blot analysis of MEG-01 RNA detected a 3.7-kilobase transcript, suggesting that a full-length cDNA has been identified. PTPase MEG cDNA contains an open reading frame of 926 amino acids. The cDNA has a G+C-rich 5' untranslated region of 771 nucleotides that has the potential to form stable stem-loop structures and has two upstream ATG codons. The predicted protein (Mr = 105,910) has no apparent membrane-spanning region and contains a single protein-tyrosine-phosphatase domain (amino acids 659-909) that is 35-40% identical to previously described tyrosine-phosphatase domains. The recombinant phosphatase domain possesses protein-tyrosine-phosphatase activity when expressed in Escherichia coli. The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein. The identification of a protein-tyrosine-phosphatase that is related to cytoskeletal proteins implies that cell signaling activities reside not only in transmembrane receptors but in cytoskeletal elements as well."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.13.5867"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.13.5867"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Majerus P.W."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Majerus P.W."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "York J.D."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "York J.D."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Warshawsky I."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/author | "Warshawsky I."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/pages | "5867-5871"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/pages | "5867-5871"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/title | "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/title | "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1."xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1648233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1648233 |
| http://purl.uniprot.org/citations/1648233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1648233 |