| http://purl.uniprot.org/citations/16482511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16482511 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-23 is regarded as a major pro-inflammatory mediator in autoimmune disease, a role which until recently was ascribed to its related cytokine IL-12. IL-23, an IL-12p40/p19 heterodimeric protein, binds to IL-12Rbeta1/IL-23R receptor complexes. Mice deficient for p19, p40 or IL-12Rbeta1 are resistant to experimental autoimmune encephalomyelitis or collagen-induced arthritis. Paradoxically, however, IL-12Rbeta2- and IL-12p35-deficient mice show remarkable increases in disease susceptibility, suggesting divergent roles of IL-23 and IL-12 in modulating inflammatory processes. IL-23 induces IL-17, which mediates inflammation and tissue remodeling, but the role of IL-12 in this respect remains unidentified. We investigated the roles of exogenous (recombinant) and endogenous (macrophage-derived) IL-12 and IL-23, on IL-17-induction in human T-cells. IL-23 enhanced IL-17 secretion, as did IL-2, IL-15, IL-18 and IL-21. In contrast, IL-12 mediated specific inhibition of IL-17 production. These data support the role of IL-23 in inflammation through stimulating IL-17 production by T lymphocytes, and importantly indicate a novel regulatory function for IL-12 by specifically suppressing IL-17 secretion. These data therefore extend previous reports that had indicated unique functions for IL-23 and IL-12 due to distinct receptor expression and signal transduction complexes, and provide novel insights into the regulation of immunity, inflammation and immunopathology."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200535239"xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "Ottenhoff T.H."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "de Boer T."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "Verreck F.A."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "de Waal Malefyt R."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "Savage N.D."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "Hoeve M.A."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/author | "Langenberg D.M."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/pages | "661-670"xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/title | "Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells."xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/16482511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16482511 |
| http://purl.uniprot.org/citations/16482511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16482511 |
| http://purl.uniprot.org/uniprot/P40933#attribution-331A0C4CA3F3DFE64A6D184CF1A2BC80 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
| http://purl.uniprot.org/uniprot/P40933#attribution-6DBEED08D2955723B76A8C21AFB59464 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
| http://purl.uniprot.org/uniprot/Q14116#attribution-331A0C4CA3F3DFE64A6D184CF1A2BC80 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
| http://purl.uniprot.org/uniprot/Q14116#attribution-6DBEED08D2955723B76A8C21AFB59464 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
| http://purl.uniprot.org/uniprot/O60674#attribution-8E635BD112194A205B9C9B35B9ABFBD5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
| http://purl.uniprot.org/uniprot/Q62120#attribution-8E635BD112194A205B9C9B35B9ABFBD5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |
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| http://purl.uniprot.org/uniprot/Q9HBE4#attribution-6DBEED08D2955723B76A8C21AFB59464 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16482511 |