| http://purl.uniprot.org/citations/16488391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16488391 | http://www.w3.org/2000/01/rdf-schema#comment | "We conducted a study on the mechanism of KAI1/CD82-mediated suppression of tumor invasiveness and metastasis, and examined its effect on MMP-9 activity and the TIMP1 levels in H1299 human non-small cell lung carcinoma cells. The H1299 human lung carcinoma cells were transfected with pcDNA3.1-CD82 and stable transfectant clones that had a high KAI1/CD82 expression were obtained. We performed Western blot analysis, cell invasion assay, gelatin zymography, and RT-PCR to assess the KAI1/CD82 expression and tumor invasiveness, the MMP-9 activity, the MMP-9 mRNA and protein levels, and the TIMP1 levels in the H1299/CD82 transfectant cells and compared the results with those of the control groups. The H1299/CD82 transfectants exhibited significant suppression of cell invasion, reduced MMP9 enzyme activity, elevated MMP9 mRNA and MMP-9 protein levels, and elevated TIMP1 levels. It may be postulated that KAI1/CD82 over-expression in the H1299 non-small cell lung carcinoma cells suppresses the tumor invasiveness and metastatic potential by inducing MMP9 inactivation via the up-regulation of TIMP1."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.01.153"xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Lee W.K."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Lim Y."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Park K.M."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Surendran S."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Han C.W."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/author | "Jee B.K."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/pages | "655-661"xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/title | "KAI1/CD82 suppresses tumor invasion by MMP9 inactivation via TIMP1 up-regulation in the H1299 human lung carcinoma cell line."xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/16488391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16488391 |
| http://purl.uniprot.org/citations/16488391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16488391 |
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