| http://purl.uniprot.org/citations/16488622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16488622 | http://www.w3.org/2000/01/rdf-schema#comment | "4-1BB, one of co-stimulatory molecules, is a member of TNF receptor superfamily and expressed on T cells upon TCR ligation. We have shown that 4-1BB is a co-stimulatory molecule enhancing cell cycle progression and inhibiting activation-induced cell death of CD8+ T cells by enhancing TCR signaling pathways. Here, we first report that the cross-linking of 4-1BB increased the expression of IL-13 mRNA and protein, and its secretion apparently via calcineurin, a Ca2+/calmodulin-dependent phosphatase. Ligation of 4-1BB with p815-m-4-1BBL evoked intracellular Ca2+ level in CD8+ T cells. CD8+ T cells express IL-13 receptor alpha1 mRNA. Incubation with anti-IL-13 blocking mAb reduced proliferation of CD8+ T cells enhanced by 4-1BB, and the treatment of CD3/4-1BB-ligated CD8+ T cells with recombinant IL-13 enhances cell proliferation, indicating that 4-1BB-induced IL-13 expression is partially responsible for the CD8+ T cell expansion in an autocrine or paracrine manner."xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2005.12.003"xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/author | "Shin S.M."xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/author | "Nam K.O."xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/pages | "87-94"xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/title | "Cross-linking of 4-1BB up-regulates IL-13 expression in CD8(+) T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/16488622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16488622 |
| http://purl.uniprot.org/citations/16488622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16488622 |
| http://purl.uniprot.org/uniprot/#_P20109-mappedCitation-16488622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/#_P20334-mappedCitation-16488622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/#_Q3U3R1-mappedCitation-16488622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/#_Q8R037-mappedCitation-16488622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/P20109 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/Q8R037 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/P20334 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16488622 |
| http://purl.uniprot.org/uniprot/Q3U3R1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16488622 |