| http://purl.uniprot.org/citations/16488880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16488880 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs carrying premature stop codons (PTC). In humans, NMD depends on the RNA- and DNA-dependent 5'-3' helicase UPF1 and six other gene products referred to as SMG1, UPF2, UPF3, EST1A/SMG6, EST1B/SMG5, and EST1C/SMG7. The NMD machinery is also thought to coordinate mRNA nuclear export and translation and to regulate the levels of several physiologic transcripts. Furthermore, in a process named SMD, UPF1 promotes degradation of mRNAs that are bound by Staufen 1. Intriguingly, SMG1 and EST1A/SMG6 function also in DNA repair and telomere maintenance, respectively. Here, we show that UPF1 is also required for genome stability. shRNA-mediated depletion of UPF1 causes human cells to arrest early in S phase, inducing an ATR-dependent DNA-damage response. A fraction of hyperphosphorylated UPF1 associates with chromatin of unperturbed cells, and chromatin association increases in S phase and upon gamma irradiation. ATR phosphorylates UPF1 both in vitro and in vivo, and shRNA-mediated downregulation of ATR diminished the association of UPF1 with chromatin, although it did not affect NMD. Physical interaction of UPF1 with DNA polymerase delta suggests a role for human UPF1 in DNA synthesis during replication or repair."xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.01.018"xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/author | "Lingner J."xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/author | "Azzalin C.M."xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/pages | "433-439"xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/title | "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability."xsd:string |
| http://purl.uniprot.org/citations/16488880 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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