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http://purl.uniprot.org/citations/1649192http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1649192http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1649192http://www.w3.org/2000/01/rdf-schema#comment"Tumor autocrine motility factor (AMF) has been detected in and purified from serum-free conditioned medium of human HT-1080 fibrosarcoma cells. Under nonreducing conditions, AMF migrates in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a single band of 55 kDa but under reducing conditions as a band of 64 kDa. Two-dimensional polyacrylamide gel electrophoresis of the purified AMF resolved two groups of polypeptides with isoelectric points of 6.1 and 6.2 (majors), 6.35 and 6.4 (minors). Purified AMF stimulated HT-1080 cell migration in a dose-dependent fashion. The motility stimulation of the fibrosarcoma cells with AMF is associated with the phosphorylation of the AMF receptor, a 78-kDa cell surface glycoprotein (gp78), suggesting protein kinase participation in migratory signal transduction. The gene encoding gp78 was cloned from an HT-1080 fibrosarcoma complementary DNA library. The deduced sequence encodes a polypeptide of 323 amino acids. The nucleotide and predicted amino acid sequence of the gp78 reveals significant homology with the human suppressor/oncogene p53 protein."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)98859-9"xsd:string
http://purl.uniprot.org/citations/1649192http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)98859-9"xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Watanabe H."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Watanabe H."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Nabi I.R."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Nabi I.R."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Carmi P."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Carmi P."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Hogan V."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Hogan V."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Raz A."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Raz A."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Raz T."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Raz T."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Silletti S."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/author"Silletti S."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/pages"13442-13448"xsd:string
http://purl.uniprot.org/citations/1649192http://purl.uniprot.org/core/pages"13442-13448"xsd:string