| http://purl.uniprot.org/citations/16492738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16492738 | http://www.w3.org/2000/01/rdf-schema#comment | "Human systemic lupus erythematosus (SLE) and its murine model, MRL lpr/lpr mice, are well known to develop a wide range of symptoms, such as glomerulonephritis, dermatitis, and arthritis, as an immune-complex disease. However, the deposition of circulating immune complex does not fully explain the tissue specificity of disease. Tissue-specific autoantigens may also be involved in tissue inflammation. In this study, desmoglein 3 (Dsg3), a major component of epidermal desmosomes, was identified as a skin-specific autoantigen. Several murine models of skin inflammation were found to develop autoantibodies to Dsg3 tightly correlated with disease aggravation, especially in MRL lpr/lpr mice. Furthermore, SLE-prone skin disease-free FcgammaRIIb-deficient mice developed skin inflammation upon immunization with Dsg3. Taken together with histological studies, we concluded that skin-specific Dsg3 serves as an autoantigen in chronic skin inflammatory diseases accompanied by mast cell degranulation, including both murine SLE and other autoinflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0510756103"xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/author | "Nishimura H."xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/author | "Strominger J.L."xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/pages | "3292-3297"xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/title | "Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/16492738 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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