| http://purl.uniprot.org/citations/16493615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16493615 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute leukemias (ALs) are heterogeneous diseases. Functional polymorphisms in the genes encoding detoxification enzymes cause inter-individual differences, which contribute to leukemia susceptibility. The CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 polymorphisms in ALL (n = 156) and AML (n = 94) patients and 140 healthy controls were genotyped by PCR and/or PCR-RFLP using blood or bone marrow samples. No association was observed between the GSTT1 gene deletion and patients (OR = 0.8, 95% CI = 0.4-1.7 for AMLs and OR = 0.9, 95% CI = 0.5-1.6 for ALLs). Patients with ALL and AML had a higher prevalence of the GSTM1 deletions compared to controls but only the difference among adult AML patients (OR = 2.1, 95% CI = 1.0-4.2) was statistically significant. The CYP2D6*3 variant allele frequency was lower in the overall acute leukemia patients (0.6%) compared to controls (P = 0.03). CYP2D6*1/*3 genotype frequency also showed a protective association in AML patients (OR = 0.09, 95% CI = 0.01-1.7; P = 0.04). We also found a risk association for CYP2E1*5 in ALL and AML (OR = 3.6, 95% CI = 1.4-9.4 and OR = 3.9, 95% CI = 1.4-10.5, respectively). No association was found for the studied CYP2D6*4, CYP1A1*2A, and GSTT1"null" variants and the risk of acute leuke-mia (ALL or AML). This case-control study suggests a contribution of CYP2E1, CYP2D6, and GSTM1 "null" variants to the development of acute leukemias."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajh.20434"xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/author | "Ozbek U."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/author | "Erensoy N."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/author | "Hatirnaz O."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/author | "Aydin-Sayitoglu M."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/name | "Am J Hematol"xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/pages | "162-170"xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/title | "Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias."xsd:string |
| http://purl.uniprot.org/citations/16493615 | http://purl.uniprot.org/core/volume | "81"xsd:string |
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