| http://purl.uniprot.org/citations/16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16495212 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic metabolic acidosis (CMA) is associated with decreased NaCl reabsorption in the proximal tubule (PT). However, the effect of CMA on Na(+) transport in the distal tubule (DT) and collecting duct (CD) is poorly understood. Rats were placed in metabolic cages and had access to water (control), 0.28 M NH(4)Cl, or 0.28 M KCl solutions in a pair-feeding protocol for 5 days (5d). Metabolic acidosis developed within 24 h in NH(4)Cl-, but not in KCl-loaded rats. Interestingly, NH(4)Cl-but not KCl-loaded rats exhibited a significant natriuresis after 24 h of treatment. Urinary Na(+) excretion increased from 1.94 to 2.97 meq/24 h (P < 0.001) and returned to below baseline level (1.67 meq/l) after 5d of CMA. The protein abundance of the cortical Na-Cl cotransporter (NCC) remained unchanged at 24 h, but increased significantly (P < 0.01) after 5d of CMA. The protein abundance of alpha-, beta-, and gamma-subunits of the epithelial Na(+) channel (ENaC) in the cortex decreased sharply during the first 24 h and then returned to baseline levels after 5d of CMA. Interestingly, Sgk1 expression decreased after 24 h (-31%, P < 0.05) and then returned to baseline after 5d of CMA. Nedd4-2 expression was not altered during CMA. CMA enhanced serum aldosterone levels by 54% and increased the expression of aldosterone synthase in the adrenal gland by 134% after 5d of CMA. In conclusion, metabolic acidosis has dual effects on urinary Na(+) excretion. The early natriuresis results from decreased Na(+) reabsorption in the PT and Sgk1-related decreased ENaC activity in the DT and CD. Aldosterone-induced upregulation of NCC, Sgk1, and ENaC likely contributes to the antinatriuretic phase of metabolic acidosis. This adaptation prevents Na(+) wasting and volume depletion during chronic acid insult."xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00338.2005"xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/author | "Sheriff S."xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/author | "Amlal H."xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/author | "Faroqui S."xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/pages | "F322-31"xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/title | "Metabolic acidosis has dual effects on sodium handling by rat kidney."xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/16495212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16495212 |
| http://purl.uniprot.org/citations/16495212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16495212 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JVM7-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_D4A128-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_A6JY68-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_A6I8V0-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZMM4-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_B8QP49-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_F1LXA3-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_F1LPS4-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_G3V8G0-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_Q06226-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_P55018-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |
| http://purl.uniprot.org/uniprot/#_P30099-mappedCitation-16495212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16495212 |