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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/16497732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16497732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16497732 | http://www.w3.org/2000/01/rdf-schema#comment | "Coactivator-associated arginine methyltransferase-1 (CARM1) is known to enhance transcriptional activation by nuclear receptors through interactions with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17). Here, we show that CARM1 can act as a coactivator for the transcription factor nuclear factor-kappaB (NF-kappaB) and enhance NF-kappaB activity in a CBP (p300)-dependent manner. This enhancement in 293T cells was abolished by cotransfection with a specific short hairpin RNA targeted to knockdown CARM1. Chromatin immunoprecipitation demonstrated CARM1 recruitment in vivo to the promoters of NF-kappaB p65-regulated genes along with CBP and steroid receptor coactivator-1. This was accompanied by an increase in histone H3-R17 methylation as well as H3-K9 and H3-K14 acetylation, and a decrease in H3-citrulline. Immunoprecipitation with anti-p65 antibody revealed that CARM1 physically interacts with NF-kappaB p65. Furthermore, we demonstrated the physiological significance by observing that similar events occurred when THP-1 monocytic cells were stimulated with TNF-alpha or with S100b, a ligand for the receptor of advanced glycation end products, both of which are associated with diabetic complications and also known inducers of NF-kappaB and inflammatory genes in monocytes. These results demonstrate that CARM1 participates in NF-kappaB-mediated transcription through H3-R17 methylation and support a nonnuclear receptor-associated function for CARM1. They also demonstrate for the first time that CARM1 occupancy, histone H3-R17 methylation, and citrullination are regulated at the promoters of inflammatory genes in monocytes, thereby suggesting a novel role for histone arginine modifications in inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2005-0365"xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2005-0365"xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Natarajan R."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Natarajan R."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Chavez V."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Chavez V."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Lanting L."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Lanting L."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Miao F."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/author | "Miao F."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/pages | "1562-1573"xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/pages | "1562-1573"xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/title | "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/title | "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16497732 | http://purl.uniprot.org/core/volume | "20"xsd:string |