| http://purl.uniprot.org/citations/16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16498412 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch signaling plays a critical role in T-cell differentiation and leukemogenesis. We previously demonstrated that, while pre-TCR is required for thymocytes proliferation and leukemogenesis, it is dispensable for thymocyte differentiation in Notch3-transgenic mice. Notch3-transgenic premalignant thymocytes and T lymphoma cells overexpress pTalpha/pre-TCR and display constitutive activation of NF-kappaB, providing survival signals for immature thymocytes. We provide genetic and biochemical evidence that Notch3 triggers multiple NF-kappaB activation pathways. A pre-TCR-dependent pathway preferentially activates NF-kappaB via IKKbeta/IKKalpha/NIK complex, resulting in p50/p65 heterodimer nuclear entry and recruitment onto promoters of Cyclin D1, Bcl2-A1 and IL7-receptor-alpha genes. In contrast, upon pTalpha deletion, Notch3 binds IKKalpha and maintains NF-kappaB activation through an alternative pathway, depending on an NIK-independent IKKalpha homodimer activity. The consequent NF-kappaB2/p100 processing allows nuclear translocation of p52/RelB heterodimers, which only trigger transcription from Bcl2-A1 and IL7-receptor-alpha genes. Our data suggest that a finely tuned interplay between Notch3 and pre-TCR pathways converges on regulation of NF-kappaB activity, leading to differential NF-kappaB subunit dimerization that regulates distinct gene clusters involved in either cell differentiation or proliferation/leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600996"xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Frati L."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Screpanti I."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Gulino A."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Palermo R."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Vacca A."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Felli M.P."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Calce A."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Di Giovine M."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/author | "Di Mario G."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/pages | "1000-1008"xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/title | "Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia."xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16498412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16498412 |
| http://purl.uniprot.org/citations/16498412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16498412 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0F4-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T4-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |
| http://purl.uniprot.org/uniprot/#_E9Q605-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |
| http://purl.uniprot.org/uniprot/#_P0C6B2-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |
| http://purl.uniprot.org/uniprot/#_A0A494BAZ6-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |
| http://purl.uniprot.org/uniprot/#_A0AUV3-mappedCitation-16498412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16498412 |