| http://purl.uniprot.org/citations/16498457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16498457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16498457 | http://www.w3.org/2000/01/rdf-schema#comment | "Structure-specific recognition protein (SSRP1) is an 87 kDa protein that heterodimerizes with Spt16 to form FACT, a complex initially shown to facilitate chromatin transcription. Despite its crucial roles in transcription and replication, little is known about the dynamics of FACT turnover in vivo. Here, we show that SSRP1 is cleaved during apoptosis by caspase 3 and/or 7 at the DQHD(450) site. Analysis of the resulting fragments suggests that cleavage of SSRP1 generates a truncated, chromatin-associated form of FACT. Furthermore, the N-terminal product is stabilized by proteasome inhibitors and ubiquitylated in cells, suggesting degradation through the ubiquitin-proteasome pathway. These results demonstrate that SSRP1 degradation during apoptosis is a two-step process coupling caspase cleavage and ubiquitin-dependent proteolysis."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401878"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401878"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Landais I."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/author | "Landais I."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/pages | "1866-1878"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/pages | "1866-1878"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/title | "Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/title | "Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16498457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16498457 |
| http://purl.uniprot.org/citations/16498457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16498457 |
| http://purl.uniprot.org/citations/16498457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16498457 |
| http://purl.uniprot.org/citations/16498457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16498457 |