| http://purl.uniprot.org/citations/16500623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16500623 | http://www.w3.org/2000/01/rdf-schema#comment | "Murine intestinal intraepithelial lymphocytes (IELs) can be classified according to expression of a CD43 glycoform recognized by the S7 monoclonal antibody. In this study, we examined the response of S7+ and S7-IELs in mice during acute reovirus serotype 3 (Dearing strain) infection, which was confirmed by virus-specific real-time PCR. In vivo proliferation increased significantly for both S7- and S7+ IELs on day 4 post-infection as determined by BrdU incorporation; however, expression of the inducible costimulatory (ICOS) molecule, which peaked on day 7 post-infection, was upregulated on S7+ CD4+ T cells, most of which were CD4+8-IELs. In vitro ICOS stimulation by syngeneic peritoneal macrophages induced IFN-gamma secretion from IELs from day 7 infected mice, and was suppressed by treatment with anti-ICOS mAb. Additionally, IFN-gamma mRNA increased in CD4+ IELs on day 6 post-infection. These findings indicate that S7- and S7+ IELs are differentially mobilized during the immune response to reovirus infection; that the regulated expression of ICOS is associated with S7+ IELs; and that stimulation of IELs through ICOS enhances IFN-gamma synthesis during infection."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.02.031"xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/author | "Klein J.R."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/author | "Teng B.B."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/author | "Montufar-Solis D."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/author | "Garza T."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/pages | "782-790"xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/title | "Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection."xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/16500623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16500623 |
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