| http://purl.uniprot.org/citations/16504547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16504547 | http://www.w3.org/2000/01/rdf-schema#comment | "The viability of non-homologous end-joining (NHEJ)-defective mice suggests that homologous recombination (HR) might take over its role in DNA repair. To test this hypothesis, we examined gene targeting frequencies (TF) in DNA-PK(cs), Ku80 and poly(ADP-ribose) polymerase (PARP-1) nullizygous cells. We observed a 3-fold TF increase in PARP-1 knockout embryonic stem (ES) cells, which is consistent with the predicted role of PARP-1 as a switch between HR and NHEJ. To a lesser extent, such effect could be reproduced upon chemical inhibition of PARP-1. However, TF was not enhanced in Ku80- or DNA-PK(cs)-defective cells. Our study also suggests an unexpected involvement of DNA-PK(cs) in HR."xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellbi.2005.12.005"xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/author | "Masutani M."xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/author | "Dominguez-Bendala J."xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/author | "McWhir J."xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/pages | "389-393"xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/title | "Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency."xsd:string |
| http://purl.uniprot.org/citations/16504547 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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