| http://purl.uniprot.org/citations/16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16505142 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules. To evaluate the in vivo role of ERAP1, we have generated ERAP1-deficient mice. Cell surface expression of the class Ia molecules H-2Kb and H-2Db and of the class Ib molecule Qa-2 was significantly reduced in these animals. Although cells from mutant animals exhibited reduced capacity to present several self- and foreign antigens to Kb-, Db-, or Qa-1b-restricted CD8+ cytotoxic T cells, presentation of some antigens was unaffected or significantly enhanced. Consistent with these findings, mice generated defective CD8+ T cell responses against class I-presented antigens. These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20052271"xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Hill T."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Roopenian D.C."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Joyce S."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Olivares-Villagomez D."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Parekh V.V."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Dragovic S."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/author | "Mendez-Fernandez Y."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/pages | "647-659"xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/title | "In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules."xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/16505142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16505142 |
| http://purl.uniprot.org/citations/16505142 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A068BIS1-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VMT6-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGL0-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VNJ8-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VNY4-mappedCitation-16505142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16505142 |