| http://purl.uniprot.org/citations/16507907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16507907 | http://www.w3.org/2000/01/rdf-schema#comment | "Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease resulting from lack of the sarcolemmal protein dystrophin. However, the mechanism leading to the final disease status is not fully understood. Several lines of evidence suggest a role for nuclear factor (NF)-kappaB in muscle degeneration as well as regeneration in DMD patients and mdx mice. We investigated the effects of blocking NF-kappaB by inhibition of oxidative stress/lipid peroxidation on the dystrophic process in mdx mice. Five-week-old mdx mice received three times a week for 5 weeks either IRFI-042 (20 mg/kg), a strong antioxidant and lipid peroxidation inhibitor, or its vehicle. IRFI-042 treatment increased forelimb strength (+22%, P < 0.05) and strength normalized to weight (+23%, P < 0.05) and decreased fatigue (-45%, P < 0.05). It also reduced serum creatine kinase levels (P < 0.01) and reduced muscle-conjugated diene content and augmented muscle-reduced glutathione (P < 0.01). IRFI-042 blunted NF-kappaB DNA-binding activity and tumor necrosis factor-alpha expression in the dystrophic muscles (P < 0.01), reducing muscle necrosis (P < 0.01) and enhancing regeneration (P < 0.05). Our data suggest that oxidative stress/lipid peroxidation represents one of the mechanisms activating NF-kappaB and the consequent pathogenetic cascade in mdx muscles. Most importantly, these new findings may have clinical implications for the pharmacological treatment of patients with DMD."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2006.050673"xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Messina S."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Aguennouz M."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Mazzeo A."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Vita G."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Altavilla D."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Squadrito F."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Marini H."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Minutoli L."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Seminara P."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Bitto A."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/author | "Monici M.C."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/pages | "918-926"xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/title | "Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice."xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/16507907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16507907 |
| http://purl.uniprot.org/citations/16507907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16507907 |
| http://purl.uniprot.org/uniprot/#_A0A023ZT56-mappedCitation-16507907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16507907 |
| http://purl.uniprot.org/uniprot/#_A0A023ZTV5-mappedCitation-16507907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16507907 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1NN66-mappedCitation-16507907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16507907 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS2-mappedCitation-16507907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16507907 |