| http://purl.uniprot.org/citations/16511241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16511241 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin-mediated protein modification via covalent attachment of ubiquitin has emerged as one of the most common regulatory processes in all eukaryotes. Nedd4-2, closely related to neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4), is a multimodular ubiquitin-protein ligase comprised of four WW domains and a Hect domain. The WW domains recognize the proline-rich motifs on the multi-subunit amiloride-sensitive epithelial sodium channel (ENaC). To gain insights into the binding of the WW domain to proline-rich peptides, a protein fragment (78 amino acids) containing the fourth WW domain (WW4) of the Nedd4-2 protein was purified and crystallized and X-ray diffraction data were collected. A data set was obtained to 2.5 A resolution from a cryocooled single crystal at a synchrotron source. The crystals belong to the tetragonal space group P4(1)2(1)2 (or P4(3)2(1)2), with unit-cell parameters a = b = 113.43, c = 103.21 A. Analysis of the self-rotation function suggests the presence of four WW4 molecules in the asymmetric unit, with a high unit-cell solvent content of 74%."xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.org/dc/terms/identifier | "doi:10.1107/s174430910503767x"xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/author | "Narayana N."xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/author | "Umadevi N."xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/name | "Acta Crystallogr Sect F Struct Biol Cryst Commun"xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/pages | "1084-1086"xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/title | "Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase."xsd:string |
| http://purl.uniprot.org/citations/16511241 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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