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| http://purl.uniprot.org/citations/16513334 | http://www.w3.org/2000/01/rdf-schema#comment | "We report a fully comprehensive data-mining exercise, involving an estimated total of 590,000 similarity searches, using agents available on the Internet to search for homologies to polypeptide sequences assigned to the category 'development' in the Gene Ontology Consortium AmiGO database (www.godatabase.org). The results indicate that of 552 such developmental sequences only 78 are shared between all three kingdoms, 72 are shared only between fungi and animals, 58 sequences are shared between plants and fungi, and four sequences were common only to Dictyostelium and fungi. No sequences were strictly fungus specific, but 68 occurred only in plants (Viridiplantae) and 239 occurred only in animals (Metazoa). Although some homology was indicated for a total of 219 fungal sequences, 143 (65%) of the matches returned were assigned E-values of 0.05 and must be categorised as weak similarities at best. The majority of the highly similar matches found in this survey proved to be between sequences involved in basic cell metabolism or essential eukaryotic cell processes (enzymes in common metabolic pathways, transcription regulators, binding proteins, receptors and membrane proteins). What is lacking is cross-kingdom similarity in the management processes that regulate multicellular development. The crown group of eukaryotic kingdoms control and regulate their developmental processes in very different ways. Unfortunately, we know nothing about molecular control of multicellular fungal developmental biology."xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mycres.2006.01.003"xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/author | "Moore D."xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/author | "Meskauskas A."xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/name | "Mycol Res"xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/pages | "251-256"xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/title | "A comprehensive comparative analysis of the occurrence of developmental sequences in fungal, plant and animal genomes."xsd:string |
| http://purl.uniprot.org/citations/16513334 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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