| http://purl.uniprot.org/citations/16513351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16513351 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila phototransduction cascade serves as a paradigm for characterizing the regulation of sensory signaling and TRP channels in vivo . Activation of these channels requires phospholipase C (PLC) and may depend on subsequent production of diacylglycerol (DAG) and downstream metabolites . DAG could potentially be produced through a second pathway involving the combined activities of a phospholipase D (PLD) and a phosphatidic acid (PA) phosphatase (PAP). However, a role for a PAP in the regulation of TRP channels has not been described. Here, we report the identification of a PAP, referred to as Lazaro (Laza). Mutations in laza caused a reduction in the light response and faster termination kinetics. Loss of laza suppressed the severity of the phenotype caused by mutation of the DAG kinase, RDGA , indicating that Laza functions in opposition to RDGA. We also showed that the retinal degeneration resulting from overexpression of the PLD was suppressed by elimination of Laza. These data demonstrate a requirement for a PLD/PAP-dependent pathway for achieving the maximal light response. The genetic interactions with both rdgA and Pld indicate that Laza functions in the convergence of both PLC- and PLD-coupled signaling in vivo."xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.02.057"xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/author | "Kwon Y."xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/author | "Montell C."xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/pages | "723-729"xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/title | "Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response."xsd:string |
| http://purl.uniprot.org/citations/16513351 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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