| http://purl.uniprot.org/citations/16516152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16516152 | http://www.w3.org/2000/01/rdf-schema#comment | "The biochemical differences between simple steatosis, a benign liver disease, and non-alcoholic steatohepatitis, which leads to cirrhosis, are unclear. Fat aussie is an obese mouse strain with a truncating mutation (foz) in the Alms1 gene. Chow-fed female foz/foz mice develop obesity, diabetes, and simple steatosis. We fed foz/foz and wildtype mice a high-fat diet. Foz/foz mice developed serum ALT elevation and severe steatohepatitis with hepatocyte ballooning, inflammation, and fibrosis; wildtype mice showed simple steatosis. Biochemical pathways favoring hepatocellular lipid accumulation (fatty acid uptake; lipogenesis) and lipid disposal (fatty acid beta-oxidation; triglyceride egress) were both induced by high-fat feeding in wildtype but not foz/foz mice. The resulting extremely high hepatic triglyceride levels were associated with induction of mitochondrial uncoupling protein-2 and adipocyte-specific fatty acid binding protein-2, but not cytochrome P4502e1 or lipid peroxidation. In this model of metabolic syndrome, transition of steatosis to steatohepatitis was associated with hypoadiponectinemia, a mediator of hepatic fatty acid disposal pathways."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.02.032"xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Petrovsky N."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Teoh N.C."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Arsov T."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Yeh M.M."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Nolan C.J."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Farrell G.C."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/author | "Larter C.Z."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/pages | "1152-1159"xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/title | "Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice."xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/16516152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16516152 |
| http://purl.uniprot.org/citations/16516152 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16516152 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RMI8-mappedCitation-16516152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16516152 |
| http://purl.uniprot.org/uniprot/#_Q8K4E0-mappedCitation-16516152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16516152 |
| http://purl.uniprot.org/uniprot/Q8K4E0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16516152 |
| http://purl.uniprot.org/uniprot/A0A1D5RMI8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16516152 |